12th INTERNATIONAL SYMPOSIUM ON
MICROSOMES AND DRUG OXIDATIONS
This Symposium is dedicated to Professor Urs A Meyer
in recognition of his outstanding contribution
to the field of pharmacogenetics
ORGANIZING COMMITTEE
The Symposium is organized jointly by INSERM U128 and SANOFI-RECHERCHE
Patrick Maurel (INSERM, Chair)
Yves Berger (SANOFI-RECHERCHE)
Claude Bonfils (INSERM)
Martine Daujat (INSERM)
Gérard Fabre (SANOFI-RECHERCHE)
Reinhard Lange (INSERM, Treasury)
Anne-Marie Menut (SANOFI-RECHERCHE)
Lydiane Pichard (INSERM)
Edith Raulet (INSERM, secretary)
Marie-Jo Vilarem (INSERM)
INTERNATIONAL ADVISORY COMMITTEE
Alexander Archakov (Russia)
Donald J Birkett (Australia)
Brian Burchell (United Kingdom)
Minor J Coon (USA)
Francesco De Matteis (Italy)
Ronald W Estabrook (USA)
Yoshiaki Fujii-Kuriyama (Japan)
Joyce Goldstein (USA)
Frank J Gonzalez (USA)
Oliver Hankinson (USA)
Magnus Ingelman-Sundberg (Sweden)
Tetsuya Kamataki (Japan)
Anthony YH Lu (USA)
Daniel Mansuy (France)
Urs A Meyer (Switzerland)
Franz Oesch (Germany)
Allan B Okey (Canada)
Paul Ortiz de Montellano (USA)
Elisabeth Shephard (United Kingdom)
David Waxman (USA)
The 3 graces (Montpellier)
SYMPOSIUM SECRETARIATS
- Registration, accommodation and abstracts are being handled by:
ALPHA VISA / ISMDO 98
624, rue des Grèzes
34070 Montpellier
France
Tel: +33 (0)4 67 45 56 77
Fax: +33 (0)4 67 45 57 97
E-mail: visa@imaginet.fr
- For any further information concerning the scientific side of the
symposium, please contact:
ISMDO 98 - Organizing Committee
INSERM U 128
1919, Route de Mende
34293 Montpellier (cedex 5), France
Tel: +33 (0)4 67 61 33 63
Fax: +33 (0)4 67 52 36 81
E-mail: maurel@crbm.cnrs-mop.fr
Esplanade of the Corum (Montpellier)
SPONSORS
Sanofi-Recherche
Région Languedoc-Roussillon
District de Montpellier
INSERM
CNRS
INRA
Ministère des Affaires Etrangères
Affimetrix
Astra Charnwood
Biopredic
Eli Lilly & Co.
Glaxo Wellcome France
Groupe Fournier
Iffa Credo
Institut de Recherches Internationales Servier (IRIS)
Institut de Recherche Jouveinal
Institut de Recherche Pierre Fabre
Laboratoires Lafon
Merck & Co., Inc. - USA
Merial
Pharmacia and Upjohn
Rhône Poulenc Rorer
Roussel Uclaf
Schering Plough Research Institute
SmithKline Beecham
Stabiligen
Synthélabo-Recherche
WELCOME
MESSAGE FROM THE ORGANIZING COMMITTEE
Dear Colleagues,
The Organizing Committee takes a great pleasure in welcoming you
to Montpellier for the 12th International Symposium on Microsomes and Drug
Oxidations.
In a period where the so-called “in vitro methods and models”
are being increasingly considered as part of the battery of tests required
by the Regulatory Agencies for the prediction of metabolic pathways, drug
interactions and other side effects, we felt important to focus this symposium
on the human drug metabolizing enzymes. Emphasis has been placed also on
both traditional and more recently developped aspects including Pharmacogenetics,
gene regulation (notably concerning the CYP3A family), modelling of microsomal
CYP active sites, the use of transgenic animals, CYPs and gene therapy
of cancers, the problems of AIDS drugs, and ABC-transporters.
This proceeding represents the official scientific program and
record of all the presentations given at this symposium. At the time of
printing, approximately 650 scientists representing 36 countries, have
been registering to the symposium. We should like to express our gratitude
to the members of the International Advisory Committe and to the Chairmen
for their help and guidance during the preparation of the symposium. We
are also grateful to the speakers for accepting to give updated overviews
of the researches in their own field of investigation. We should like to
extend our thanks to all participants, especially those who have prepared
posters for sharing their recent findings. Indeed, the success of the symposium
depends greatly on the contribution of all delegates not only during the
plenary lectures, parallel sessions and posters discussions but also on
your vigorous and continually expanding interest in the various aspects
in the field of drug metabolism. Finally, we thank the sponsors whose financial
support made the symposium possible.
Besides the scientific parts of the symposium, we have prepared
a social program with the hope that it will allow you not only to relax
after hard days of work but also to favour new contacts and collaborations
which are often the source of the scientific improvements.
Patrick Maurel
Chairman of the Organizing Committee
IMPORTANT DATE TO NOTE
July 20 1998: Opening of the Symposium
Saint Anne church (Montpellier)
HOW TO REGISTER (in
brief)
see more detailed information below
1. Complete Registration Form
2. Complete Accommodation Form
3. Complete Original Abstract Form (optional)
4. Send all documents together with appropriate fees to
Alpha Visa / ISMDO 98
624 Rue des Grèzes
34070 Montpellier France
Tel. +33 (0)4 67 45 56 77 - Fax. +33 (0)4 67 45 57 97
Email: visa@imaginet.fr
SCIENTIFIC PROGRAM
The scientific program will consist of plenary lectures in the morning
(Pasteur auditorium), three parallel session lectures in the afternoon
(Pasteur auditorium, Einstein auditorium and Salle Rondelet), oral communication
from selected posters at lunch time (Einstein auditorium), and poster sessions
(Espace Joffre). In addition, a scientific exhibition will be held during
the symposium (Espace Joffre).
Plenary sessions (and posters sessions):
Gene regulation
The CYP3A family
CYP active site topology
Molecular mechanisms of chemical toxicity
Parallel sessions (and posters sessions):
Transgenic animals to predict drug metabolism
Phase II enzymes
Xenobiotic-metabolizing enzymes in animals for food production
In vitro models for drug metabolism and toxicity
The peroxysome proliferator activated receptors
Topographical localisation of drug-metabolizing enzymes
Induction by drugs of immune-mediated adverse reactions
Endogenous substrates of drug-metabolizing enzymes
Impact of diseases on detoxication
Pharmacogenetics of CYPs and other drug-metabolizing enzymes
Drug-metabolizing enzymes in lymphocytes
CYPs, anti-cancer drugs and gene therapy
Activation and disposition of AIDS drugs
Ah-Receptor and regulation of drug-metabolizing enzymes
Non invasive methods for assessing drug-metabolizing enzymes in man
ABC transporters and drug disposition
Drug interactions
Extrahepatic drug-metabolizing enzymes
Other poster sessions:
Nitric oxide synthases
Drug-metabolizing enzyme degradation
Chemical carcinogenesis, mutagenesis and teratogenesis
Heme regulation of CYP genes
Biotechnology tools
Non mammalian species
Other
Oral communication sessions:
Five oral communications will be presented in Auditorium Einstein every
day between 12:30 and 13:30. In order to encourage young scientists to
participate actively at the Symposium, these communications should be given
preferentially by PhD students or by post-doctoral fellows. The communications
to be presented have been selected by the co-chairmen of the session, from
the abstracts submitted for the poster sessions.
TIME
SCHEDULE AND LOCATIONS
TUESDAY JULY 21
8:00 - 8:30 Auditorium Pasteur
Opening of the Symposium: P Maurel (France), M J Coon (USA)
8:30 - 11:30 Auditorium Pasteur
Plenary session 1: Gene regulation. Chairs: F Gonzalez (USA),
E Shephard (UK)
8:30-8:35. Introduction: F Gonzalez (USA)
8:35-9:03. PL1-1: F Gonzalez (USA): Conditional gene targeting
to study transcription factors and xenobiotic-metabolizing enzymes
9:03-9:31. PL1-2: D Waxman (USA): Role of the STAT signal transduction
pathway in growth hormone-regulated P450 gene control
9:31-10:00. PL1-3: E Shephard (UK): Mechanism of phenobarbital induction
10:00 - 10:30 Espace Joffre : Coffee break, Posters, Commercial
Exhibition
10:30-10:58. PL1-4: A Jaiswal (USA): Mechanism of gene activation by
oxidative stress, the NQO genes
10:58-11:25. PL1-5: M Lang (Sweden): Regulation of expression of hepatic
CYP2A5: possible interaction between transcription and mRNA stabilization
11:25-11:30. Conclusion: E Shephard (UK)
11:30 - 14:30 Espace Joffre: Lunch, Posters, Commercial Exhibition
12:30 - 13:30 Auditorium Einstein
Oral communications (selected posters). Chairs: B Burchell (UK),
F De Matteis (Italy)
12:30-12:42. OC-1. Y Morel (France): Nuclear factor (NF-1) mediates
CYP1A1 gene autoregulation via a redox mechanism
12:42-12:54. OC-2. J Schuetz (USA): Divergent regulation of rat MDR1A
and MDR1B by P53 in response to DNA damaging agents
12:54-13:06. OC-3. T Schulz-Utermoehl (UK): Polymorphic debrisoquine
4-hydroxylase activity in the rat is due to differences in CYP2D2 expression
13:06-13:18. OC-4. P Costet (France): Role of the nuclear receptor
PPAR? in lipid homeostasis, steatosis and obesity
13:18-13:30. OC-5. S Fournel-Gigleux (France): Evidence for an internal
signal sequence mediating the membrane targeting and translocation of the
human UDP-glucuronosyltransferase UGT1A6 into the endoplasmic reticulum
14:30 - 16:15 Salle Rondelet
Session 1: Transgenic animals to predict drug metabolism. Chairs:
T Kamataki (Japan), A Okey (Canada)
14:30-14:35. Introduction: T Kamataki (Japan)
14:35-14:58. S1-1. D Nebert (USA): Human gene polymorphisms of drug-metabolizing
enzymes (DMEs) and recptor controlling DME gene expression: possible elucidation
of functional and toxicokinetic significance in the mouse by a new “knock-in”
technique
14:58-15:22. S1-2. C Omiecinski (USA): Phenobarbital responsiveness
conferred by the 5’-flanking region of the rat CYP2B2 gene in transgenic
mice
15:22-15:46. S1-3. Y Li (Japan): Evaluation of human fetus-specific
cytochrome P450 3A7 expressed in transgenic mice: its role in carcinogenesis
and drug metabolism
15:46-16:10. S1-4. R Wolf (UK): Glutathione S-transferase in trangenic
mice
16:10-16:15. Conclusion: A Okey (Canada)
14:30 - 16:15 Auditorium Pasteur
Session 2: Phase II enzymes. Co-chairs: P Mackenzie (Australia),
Y Yamazoe (Japan)
14:30-14:35. Introduction: P Mackenzie (Australia)
14:35-14:58. S2-1. I Owens (USA): A required buried ?-helical structure
in the human bilirubin UGT1A1 contains a non-replaceable phenylalanine
14:58-15:22. S2-2. P Board (Australia): Characterization of the zeta
class glutathione transferases
15:22-15:46. S2-3. F Oesch (Germany): Epoxide hydrolases
15:46-16:10. S2-4. Y Yamazoe (Japan): Sulfotransferases
16:10-16:15. Conclusion: Y Yamazoe (Japan)
14:30 - 16:15 Auditorium Einstein
Session 3. Xenobiotic-metabolizing enzymes in animals for food production.
Chairs: P Galtier (France), JP Thénot (France)
14:30-14:35. Introduction: P Galtier (France)
14:35-14:58. S3-1. RF Witkamp (Netherlands): Patho-pharmacology of
pig liver cytochromes P450
14:58-15:22. S3-2. P Galtier (France): Xenobiotic-metabolizing cytochromes
P450 in sheep
15:22-15:46. S3-3. M Celander (Sweden): Cytochrome P450 in fish: regulation
and localisation, and sensitivity to environmental pollutants
15:46-16:10. S3-4. H Tjalve (Sweden): Interspecies differences in extrahepatic
bioactivation of aflatoxin B1
16:10-16:15. Conclusion: JP Thénot (France)
16:15 - 16:45 Espace Joffre : Coffee break, Posters, Commercial
Exhibition
16:45 - 18:45 Auditorium Pasteur
Session 4. In vitro models for drug metabolism and toxicity.
Chairs: D Birkett (Australia), G Fabre (France)
16:45-16:50. Introduction: G Fabre (France)
16:50-17:12. S4-1. R Gasser (Switzerland): In vitro models to determine
human metabolic pathways and CYP isoform specificity of new drugs: discussion
of common errors and how to avoid them
17:12-17:34. S4-2. A. Li (USA): In vitro models for the evaluation
of drug-mediated toxicity and induction of xenobiotic metabolism
17:34-17:56. S4-3. J Miners (Australia): In vitro models for drugs
eliminated by conjugating enzymes
17:56-18:18. S4-4. J Sinclair (USA): Acetaminophen hepatotoxicity increased
by alcohol and other drugs: correlation between in vitro and in vivo models
18:18-18:40. S4-5. JB Houston (UK): In vitro-in vivo models for clearance
18:40-18:45. Conclusion: D Birkett (Australia)
16:45 - 18:30 Salle Rondelet
Session 5: The peroxisome proliferator activated receptors.
Chairs: EF Johnson (USA), G Gibson (UK)
16:45-16:50. Introduction: E Johnson (USA)
16:50-17:13. S5-1. E Johnson (USA): Liver expression of human PPAR?:
non productive mRNA splicing contributes to low abundance
17:13-17:37. S5-2. C Palmer (UK): Ligands and physiological roles of
PPAR
17:37-18:01. S5-3. W Wahli (Switzerland): Peroxisome proliferator-activated
receptors (PPARs) as mediators of fatty acid and ecosanoid signalling
18:01-18:25. S5-4. J Reddy (USA): PPAR co-activators
18:25-18:30. Conclusion: G Gibson (UK)
16:45 - 18:30 Auditorium Einstein
Session 6: Topographical localisation of drug-metabolizing enzymes.
Chairs: MJ Coon (USA), F Oesch (Germany)
16:45-16:50. Introduction: F Oesch (Germany)
16:50-17:13. S6-1. D Sabatini (USA): Cellular sorting: a general overview
17:13-17:37. S6-2. B Kemper (USA): Mechanisms of retention of P450s
in the endoplasmic reticulum
17:37-18:01. S6-3. D Pessayre (France): P450s and P450-metabolite adducts
are transported to the plasma membrane and serve as antigenic targets in
immune reactions
18:01-18:25. S6-4. M Ingelman-Sundberg (Sweden): Localisation of CYP2E1
on the outer surface of the plasma membrane
18:25-18:30. Conclusion: MJ Coon (USA)
WEDNESDAY JULY 22
8:00 - 11:30 Auditorium Pasteur
Plenary session 2. The CYP3A family. Chairs: PS Guzelian (USA),
P Maurel (France)
8:00-8:05. Introduction: P Maurel (France)
8:05-8:34. PL2-1. PF Guengerich (USA): Catalytic properties of cytochrome
P450 3A enzymes
8:34-9:02. PL2-2. SA Wrighton (USA): The CYP3A family. Pharmacological
and toxicological implications
9:02-9:31. PL2-3. PB Watkins (USA): The CYP3A family: extrahepatic
tissue distribution and role
9:31-10:00. PL2-4. S Kliewer (USA): The pregnane X receptor regulates
CYP3A gene expresion
10:00 - 10:30 Espace Joffre : Coffee break, Posters, Commercial
Exhibition
10:30-10:58. PL2-5. L Quattrochi (USA): Novel regulation of CYP3A by
dexamethasone and pregnenolone 16a-carbonitrile
10:58-11:25. PL2-6. MJ Vilarem (France): Glucocorticoid receptor mediated
induction of human CYP3A genes by rifampicin
11:25-11:30. Conclusion: P Guzelian (USA)
11:30 - 14:30 Espace Joffre: Lunch, Posters, Commercial Exhibition
12:00 - 14:00 Salle Joffre 5: Meeting of the International Advisory
Committee
12:30 - 13:30 Auditorium Einstein
Oral communications (selected posters). Chairs: Y Fujii-Kuriyama
(Japan), A Boobis (UK)
12:30-12:42. OC-6. F Roussel (USA): Functional importance of residues
located in SRS1 of human CYP3A4
12:42-12:54. OC-7. KE Kenworthy (UK): The simultaneous metabolism and
binding of testosterone and diazepam in a recombinant CYP3A4 enzyme system
12:54-13:06. OC-8. J Smart (UK): Genetic polymorphism within
the CYP1A1 promoter region and Ah receptor gene: possible association with
the high CYP1A1 inducibility phenotype
13:06-13:18. OC-9. R McLellan (Sweden): Functional analysis and distribution
of a novel human cytochrome P4501B1 allele
13:18-13:30. OC-10. M Oscarson (Sweden): CYP2A6 genotype revisited
14:30 - 16:15 Salle Rondelet
Session 7: Induction by drugs of immune-mediated adverse reactions.
Chairs: P Beaune (France), J Uetrecht (Canada)
14:30-14:35. Introduction: P Beaune (France)
14:35-14:58. S7-1. M Manns (Germany): Immune-mediated hepatitis induced
by xenobiotics
14:58-15:22. S7-2. L Pohl (USA): Oral tolerance: a possible factor
regulating immune responses against covalent adducts of xenobiotics
15:22-15:46. S7-3. S Leeder (USA): Immune consequences of drug bioactivation
15:46-16:10. S7-4. E Gleichmann (Germany): What do T cells recognize
in adverse immune reactions to chemicals?
16:10-16:15. Conclusion: J Uetrecht (Canada)
14:30 - 16:15 Auditorium Pasteur
Session 8: Endogenous substrates of drug-metabolizing enzymes.
Chairs: BS Masters (USA), MR Waterman (USA)
14:30-14:35. Introduction: BS Masters (USA)
14:35-14:58. S8-1. L Roman (USA): Expression and characterisation of
the inducible form of nitric oxide synthase
14:58-15:22. S8-2. D Rozman (Slovenia): Expression and role of
CYP51 in mammalian germ cells
15:22-15:46. S8-3. J Capdevilla (USA): Biochemical and functional properties
of the P450 arachidonic acid monooxygenase
15:46-16:10. S8-4. H Hamada (Japan): A novel P450 which biotransforms
all-trans and 9-cis retinoic acid into inactive metabolites
16:10-16:15. Conclusion: MR Waterman (USA)
14:30 - 16:15 Auditorium Einstein
Session 9: Impact of diseases on detoxication. Chairs: A Guillouzo
(France), C Ioannides (UK)
14:30-14:35. Introduction: C Ioannides (UK)
14:35-14:58. S9-1. K Renton (Canada): The effect of infectious disease
on the regulation of cytochromes P450
14:58-15:22. S9-2. GC Farrell (Australia): Cytochrome P450 expression
in liver disease
15:22-15:46. S9-3. CO Watlington (USA): Role of renal cytochromes P450
in the etiology of hypertension
15:46-16:10. S9-4. RA Blouin (USA): Expression and regulation of xenobiotic-metabolizing
enzymes in obesity
16:10-16:15. Conclusion: A Guillouzo (France)
16:15 - 16:45 Espace Joffre : Coffee break, Posters, Commercial
Exhibition
16:45 - 18:45 Auditorium Pasteur
Session 10: Pharmacogenetics of CYPs and other drug-metabolizing
enzymes. Co-chairs: J Goldstein (USA), M Eichelbaum (Germany)
16:45-16:50. Introduction: J Goldstein (USA)
16:50-17:12. S10-1. C Dolphin (UK): Polymorphisms and mutations of
human flavin-containing monooxygenases
17:12-17:34. S10-2. W Evans (USA): Thiopurine S-methyltransferase (TPMT)
polymorphism: molecular mechanisms and clinical importance
17:34-17:56. S10-3. J Goldstein (USA): Polymorphisms in human CYP2C19
17:56-18:18. S10-4. I Roots (Germany): Polymorphisms in drug metabolism
and cancer risk
18:18-18-40. S10-5. U Meyer (Switzerland): Therapeutic lessons from
pharmacogenetics: building a better patient
18:40-18:45. Conclusion: M Eichelbaum (Germany)
16:45 - 18:30 Salle Rondelet
Session 11: Drug-metabolizing enzymes in lymphocytes. Chairs:
M Ingelman-Sundberg (Sweden), J Raucy (USA)
16:45-16:50. Introduction: M Ingelman-Sundberg (Sweden)
16:50-17:09. S11-1. S Carpenter (USA): Use of human peripheral blood
lymphocytes for assessing ethanol-mediated induction of hepatic CYP2E1
17:09-17:28. S11-2. A Rannug (Sweden): Regulation of CYP1A1 in human
lymphocytes by UV-light, tryptophan derivatives and seasonal variations
17:28-17:47. S11-3. MR Franklin (USA): Comparative analysis of phase
II drug metabolizing enzymes in rat lymphocytes and liver in response to
known inducers
17:47-18:06. S11-4. A Rane (Sweden): Expression of human cytochromes
P450 in blood elements
18:06-18:25. S11-5. M Romkes (USA): CYP2D6 expression in lymphocytes
and the relationship to in vivo debrisoquine hydroxylation
18:25-18:30. Conclusion: J Raucy (USA)
16:45 - 18:30 Auditorium Einstein
Session 12: CYPs, anti-cancer drugs and gene therapy. Chairs:
P Dansette (France), D Waxman (USA)
16:45-16:50. Introduction: P Dansette (France)
16:50-17:09. S12-1. L Chen (USA): Cytochrome P450 and gene therapy
for cancer
17:09-17:28. S12-2. A Chiocca (USA): Preclinical efficacy and safety
studies for rRp450, a selective oncolytic virus that expresses the cyclophosphamide-susceptibility
gene, CYP2B1
17:28-17-47. S12-3. G Chabot (France): Are tumor cytochromes P450 (CYPs)
important for the chemosensitivity of human cancers?
17:47-18:06. S12-4. T Cresteil (France): Metabolism of taxol and taxotere
by human cytochromes P450
18:06-18:25. S12-5. D Kupfer (USA): Role of CYPs in metabolic activation
of tamoxifen
18:25-18:30. Conclusion: D Waxman (USA)
18:45 - 19:45 Auditorium Pasteur
Session in honor to Professor Urs A Meyer
THURSDAY JULY 23
8:30 - 11:30 Auditorium Pasteur
Plenary session 3: CYP active site topology. Chairs: D Mansuy
(France), P Ortiz de Montellano (USA)
8:30-8:35. Introduction: D Mansuy (France)
8:35-9:03. PL3-1. D Mansuy (France): Topology of active site of human
cytochromes P450 2C
9:03-9:31. PL3-2. JR Halpert (USA): Topology of CYP2Bs active sites
9:31-10:00. PL3-3. T Poulos (USA): Crystal structure of a nitric oxide
synthase heme domain
10:00 - 10:30 Espace Joffre : Coffee break, Posters, Commercial
Exhibition
10:30-10:58. PL3-4. GCK Roberts (UK): Topology of CYP2D6 and CYP3A
active sites
10:58-11:25. PL3-5. P Ortiz de Montellano (USA): Topologies of the
active sites of CYP4A enzymes
11:25-11:30. Conclusion: P Ortiz de Montellano (USA)
11:30 - 14:30 Espace Joffre: Lunch, Posters, Commercial Exhibition
12:30 - 13:30 Auditorium Einstein
Oral communications (selected posters). Chairs: J Magdalou (France),
D Pompon (France)
12:30-12:42. OC-11. I Sevrioukova (USA): Structural studies on cytochrome
P450BM-3
12:42-12:54. OC-12. D Müller-Enoch (Germany): Influence of blue
light on the topology of the active site of the mammalian monooxygenase
system
12:54-13:06. OC-13. C Falkner (USA): The negative regulation of the
rat glutathion S-transferase A2 (GSTA2) gene by glucocorticoids, C/EBPa
and ß
13:06-13:18. OC-14. L Waskell (USA): Identification of the cytochrome
P450-cytochrome b5 interprotein binding site
13:18-13:30. OC-15. A Zhukov (Sweden): Relationship between cytochrome
P450 catalytic cycling and stability: the fast degradation of CYP2E1 in
vivo is abolished by inactivation of its electron donor NADPH-cytochrome
P450 reductase
14:30 - 16:30 Auditorium Einstein: Session sponsored by Merck &
Co., Inc.-USA
Session 13: Activation and disposition of AIDS drugs. Chairs:
L Benet (USA), R Estabrook (USA)
14:30-14:35. Introduction: R Estabrook (USA)
14:35-14:57. S13-1. T Baillie (USA): Studies on the metabolism and
disposition of indinavir and related HIV protease inhibitors
14:57-15:19. S13-2. L Benet (USA): Coordinated CYP3A and P-glycoprotein
activity in protease inhibitor disposition
15:19-15:41. S13-3. D Back (UK): Drug interactions in HIV infections
15:41-16:03. S13-4. JP Somadossi (USA): Drug-drug interactions of anti-AIDS
drugs and clinical relevance
16:03-16:25. S13-5. W O’Neil (USA): The effect of disease progression
on the metabolic activation and disposition in HIV+/AIDS patients
16:25-16:30. Conclusion: L Benet (USA)
14:30 - 16:30 Salle Rondelet
Session 14: Ah receptor and regulation of drug-metabolizing enzymes.
Chairs: O Hankinson (USA), L Poellinger (Sweden)
14:30-14:35. Introduction: O Hankinson (USA)
14:35-15:02. S14-1. O Hankinson (USA): Role of the aryl hydrocarbon
receptor and the aryl hydrocarbon receptor nuclear translocator in carcinogenesis
response to hypoxia and development
15:02-15:30. S14-2. Y Fujii-Kuriyama (Japan): Function and regulation
of Ah (dioxin) receptor
15:30-15:58. S14-3. M Daujat (France): How do benzimidazole compounds
activate the Ah Receptor?
15:58-16:25. S14-4. L Poellinger (Sweden): Mechanism of signal transduction
by the Dioxin Receptor
16:25-16:30. Conclusion: L Poellinger (Sweden)
14:30 - 16:30 Auditorium Pasteur
Session 15: Non-invasive methods for assessing drug metabolism in
man. Chairs:
DS Davies (UK), PB Watkins (USA)
14:30-14:35. Introduction: DS Davies (UK)
14:35-15:02. S15-1. K Thummel (USA): In vivo assessment of CYP3A4 activity
15:02-15:30. S15-2. D Birkett (Australia): Assessment of CYP1A2 and
CYP2C9 activities
15:30-15:58. S15-3. T Andersson (Sweden): Assessment of CYP2C19 activity
15:58-16:25. S15-4. O Pelkonen (Finland): Assessment of CYP2A6 and
2E1 activities
16:25-16:30. Conclusion: PB Watkins (USA)
16:30 - 17:00 Departure for excurtion and banquet in Camargue
FRIDAY JULY 24
8:30 - 11:30 Auditorium Pasteur
Plenary session 4: Molecular Mechanisms of Chemical Toxicity. Chairs:
PF Guengerich (USA), N Vermeulen (Netherlands)
8:30-8:35. Introduction: PF Guengerich (USA)
8:35-9:03. PL4-1. S Safe (USA): Aryl hydrocarbon (Ah) receptor agonists
as xenoantiestrogenes: molecular mechanisms and applications
9:03-9:31. PL4-2. C Bradfield (USA): The Ah receptor and the search
for the toxic signal
9:31-10:00. PL4-3. N Vermeulen (Netherlands): Detrimental effects of
glutathione and glutathione conjugation
10:00 - 10:30 Espace Joffre : Coffee break, Posters, Commercial
Exhibition
10:30-10:58. PL4-4. B Van de Water (Netherlands): Stress response proteins:
modulators of chemically-induced cell death
10:58-11:25. PL4-5. H Sies (Germany): Oxidative stress: mechanisms
of endogenous protection
11:25-11:30. Conclusion: N Vermeulen (Netherlands)
11:30 - 14:30 Espace Joffre: Lunch, Posters, Commercial Exhibition
12:30 - 13:30 Auditorium Einstein
Oral communications (selected posters). Chairs: A Archakov (Russia),
M Tarbit (UK)
12:30-12:42. OC-16. JM Pascussi (France): Role of P-glycoprotein in
the species specificity of rifampicin-mediated CYP3A inducibility
12:42-12:54. OC-17. C Crespi (USA): Novel high troughput methods with
cDNA-expressed enzymes
12:54-13:06. OC-18. R Frötschl (Germany): HIV protease inhibitors
and resveratrol are potent inducers of CYP1A1
13:06-13:18. OC-19. M Paine (USA): Potent inhibition of CYP1A1 catalytic
activiyt by ketoconazole in human intestine
13:18-13:30. OC-20. A Tunek (Sweden): Reversible formation of fatty
acid esters of budesonide
14:30 - 16:30 Salle Rondelet
Session 16: ABC Transporters and drug disposition. Chairs: A
Schinkel (Netherlands), E Schuetz (USA)
14:30-14:35. Introduction: E Schuetz (USA)
14:35-14:53. S16-1. J Schuetz (USA): Regulatory interactions between
P-glycoprotein and cytochrome P450 3A
14:53-15:12. S16-2. R Kim (USA): Evaluation of P-glycoprotein-mediated
transport of prototypical CYP3A substrates reveals the overlap in shared
substrates is incomplete
15:12-15:30. S16-3. O van Tellingen (Netherlands): The role of P-glycoprotein
in drug disposition
15:30-15:49. S16-4. C Paulusma (Netherlands): The role of cMOAT/MRP2
in drug disposition
15:49-16:07. S16-5. D Keppler (Germany): Transport of conjugates by
MRP1 and MRP2
16:07-16:25. S16-6. K Lown (USA): Clinical implications of MDR expression
in human intestine
16:25-16:30. Conclusion: A Schinkel (Netherlands)
14:30 - 16:15 Auditorium Einstein
Session 17: Drug interactions. Chairs: M Strolin-Benedetti (Italy),
SA Wrighton (USA)
14:30-14:35. Introduction: M Strolin-Benedetti (Italy)
14:35-14:58. S17-1. A Rettie (USA): Development of a CYP2C9 CoMFA-homology
model to aid in the prediction of warfarin drug interactions
14:58-15:22. S17-2. M Strolin-Benedetti (Italy): Metabolism-based
drug interactions involving oral azole antifungals in humans
15:22-15:46. S17-3. L Bertilsson (Sweden): Drug interactions involving
antidepressants and other CNS drugs
15:46-15:16:10. S17-4. G Tucker (UK): In vitro to in vivo extrapolations
of drug-drug interactions
16:10-16:15. Conclusion: SA Wrighton (USA)
14:30 - 16:15 Auditorium Pasteur
Session 18: Extrahepatic drug-metabolizing enzymes. Chairs:
J Kapitulnik (Israel), H Strobel (USA)
14:30-14:35. Introduction: J Kapitulnik (Israel)
14:35-14:58. S18-1. M Vore (USA): Hormonal regulation of intestinal
glutathione and glucuronosyl transferases
14:58-15:22. S18-2. L Kaminsky (USA): Human breast cytochromes P450:
putative role in breast cancer
15:22-15:46. S18-3. H Kawashima (Japan): Brain cytochrome P450 subfamily
4F: metabolism of endogenous and exogenous substrates
15:46-16:10. S18-4. J Orly (Israel): Cytochrome P450scc and StAR expression
in the ovary: a vital mitochondrial machinery converting cholesterol to
steroid hormones
16:10-16:15. Conclusion: H Strobel (USA)
16:15 - 16:45 Espace Joffre : Coffee break, Posters, Commercial
Exhibition
16:45 - 17:20 Auditorium Pasteur
Closing of Symposium. Chairs: R Estabrook (USA), M Waterman
(USA)
16:45-17:00. Future trends in Biochemistry, Chemistry and Pharmacology.
Speakers: M Waterman (Biochemistry), D Mansuy (Chemistry), D Birkett
(Pharmacolgy)
17:00-17:10. F De Matteis: Presentation of the next meeting of the
series Microsomes and Drug Oxidations 2000
17:10-17:15. Y Fujii-Kuriyama: Presentation of the next meeting of
the series International Conference on Cytochrome P450 1999
17:15-17:20. P Maurel: Final comments and acknowledgments
INFORMATION FOR POSTER SESSIONS
Poster sessions will be held in Espace Joffre (level 1). Every poster
will be on display for two consecutive days (either 21 and 22 or 23 and
24 July from 8:00 to end of sessions, see below). Fastening material to
attach the posters will be provided at the registration desk in Espace
Joffre. All poster presenting authors are kindly asked to be present at
their poster during the two morning sessions (between 10:00 and 10:30).
Tuesday 21 and Wednesday 22 July
The posters relative to the following sessions will be on display:
Gene regulation
The CYP3A family
Transgenic animals to predict drug metabolism
Phase II enzymes
Xenobiotic-metabolizing enzymes in animals for food production
In vitro models for drug metabolism and toxicity
The peroxysome proliferator activated receptors
Topographical localisation of drug-metabolizing enzymes
Induction by drugs of immune-mediated adverse reactions
Impact of diseases on detoxication
Pharmacogenetics of CYPs and other drug-metabolizing enzymes
Drug-metabolizing enzymes in lymphocytes
CYPs, anti-cancer drugs and gene therapy
Thursday 23 and Friday 24 July
The posters relative to the following sessions will be on display:
CYP active site topology
Molecular mechanisms of chemical toxicity
Endogenous substrates of drug-metabolizing enzymes
Activation and disposition of AIDS drugs
Ah-Receptor and regulation of drug-metabolizing enzymes
Non invasive methods for assessing drug-metabolizing enzymes in man
ABC transporters and drug disposition
Drug interactions
Extrahepatic drug-metabolizing enzymes
Nitric oxide synthases
Drug-metabolizing enzyme degradation
Chemical carcinogenesis, mutagenesis and teratogenesis
Heme regulation of CYP genes
Biotechnology tools
Non mammalian species
Other
SCIENTIFIC EXHIBITION
The 12th International Symposium on Microsomes and Drug Oxidations
provides the opportunity for pharmaceutical companies, laboratory suppliers
and other companies having links with the scientific community to exhibit
their materials and services.
The exhibition will open from Tuesday 21 to Friday 24
July, 1998
Interested exhibitors should contact:
Alpha Visa / ISMDO 98
624 Rue des Grèzes
34070 Montpellier France
Tel. +33 (0)4 67 45 56 77 - Fax. +33 (0)4 67 45 57 97
Email: visa@imaginet.fr
in order to obtain further details on exhibition space and facilities.
CALL
FOR ABSTRACTS AND INSTRUCTIONS FOR THE PREPARATION OF POSTERS
Participants are encouraged to submit abstracts. These will be included
in the Proceeding of the Symposium that will be given to all participants
at the registration desk. Instructions for preparing abstracts will be
found on the ORIGINAL ABSTRACT FORM.
Dead line
The abstracts (original + 5 copies) should be sent before April 15
1998 to:
Alpha Visa / ISMDO 98
624 Rue des Grèzes
34070 Montpellier France
Tel. +33 (0)4 67 45 56 77 - Fax. +33 (0)4 67 45 57 97
E-Mail: visa@imaginet.fr
Selection of abstracts for oral communication sessions
Five oral communications will be presented in Auditorium Einstein every
day between 12:30 and 13:30. In order to encourage young scientists to
actively participate at the Symposium, these communications should be given
by PhD students or by one year post-doctoral fellows (proof required).
The communications to be presented will be selected by an International
Committee including the co-chairpersons of the session, from the abstracts
submitted for poster sessions. Please specify if you wish your abstract
to be submitted for selection for oral communication.
Important
Only those abstracts received before April 15 1998 will be considered
for oral communication.
Poster sessions
Poster sessions will take place every day in Espace Joffre. The dimensions
of the posters should not exceed a height of 120 cm and a width of 95 cm.
Fastening material suitable for light cardboard will be provided.
The temptation to overload the poster should be resisted!
Notification
During June 1998, the secretariat will notify authors regarding: i)
the acceptation of abstracts for oral communication, and ii) the day of
presentation for both oral communications and posters.
Pink flamingos in Camargue
REGISTRATION TO
THE SYMPOSIUM
Those who wish to attend the meeting should complete the enclosed registration
form and return it to the secretariat:
Alpha Visa / ISMDO 98
624 Rue des Grèzes
34070 Montpellier France
Tel. +33 (0)4 67 45 56 77 - Fax. +33 (0)4 67 45 57 97
Email : visa@imaginet.fr
Each registrant must complete a separate form. Copies of the registration
form are acceptable but additional forms can be obtained from the secretariat
on request. Remember to send your form by First Class Airmail.
Registration fees (participants) will include the following :
- Access to all the scientific sessions
- Lunch and coffee breaks
- Opening reception (July 20)
- City Hall reception (July 21)
- Wine and cheese party (July 22)
- Banquet and excursion to the Camargue (July 23)
Registration fees (accompanying persons) will include the following
:
- Opening reception (July 20)
- Visit of Montpellier historic centre
- One tour among those proposed in the list of optional events (see
page 3 - Excursions during the symposium)
- City Hall reception (July 21)
- Wine and cheese party (July 22)
- Banquet and excursion to the Camargue (July 23)
| Registration Fees |
before April 15 |
after April 15 |
Student participants
(proof of studentship required) |
1800.00 FF |
2100.00 FF |
| All other scientific participants |
3200.000 FF |
3800.00 FF |
Accompanying persons
(no scientific sessions) |
1000.00 FF |
1200.00 FF |
Payment of fees
Payment is acceptable only in French Francs. Payment of fees must accompany
all registration forms. No reservations will be confirmed until payment
is received. Payment may be made by:
- credit card (Visa Card, Euro Card, Master Card)
- bank cheque or eurocheque in french francs and payable in France
- postal money order in french francs
Bank transfers are not accepted
In the event of difficulties, please contact Alpha Visa / ISMDO 98's
office for advice
Cancellation
Cancellation should be notified in writing to ALPHA VISA / ISMDO 98's
office
Upon cancellation refunds will be made on the following conditions
:
Before May 1st 1998 : an administration charge of 250 FF will be charged
Between May 1st and June 20 1998 : 30% of the registration fees will
be charged
After June 20 1998 : no refund will be made
Substitutions may be made at any time. Such replacement is permitted
without cost provided the secretariat is informed before the start of the
symposium.
Confirmation
A letter of confirmation will be sent to each participant on receipt
of the registration form and payment. A receipt will also be sent covering
the enrolment fee and any accommodation, lunches, excursion or banquet
charges. Any balance due will be indicated.
Registration desk
The registration desk will be located at the Congress Centre "Le Corum",
Esplanade Charles de Gaulle in Montpellier
The desk will be open during the following hours :
Monday July 20 14:00 - 19:00
Tuesday July 21 8:00 - 19:00
Wednesday July 22 8:00 - 19:00
Thursday July 23 8:00 - 17:00
Friday July 24 8:00 - 18:00
Attendance verification
A certificate of attendance will be available for each participant
at the meeting desk. Invoice for registration fees and/or accommodation
can also be provided upon requirement.
Bistrot on the Place de la Comédie (Montpellier)
ACCOMMODATION
Alpha Visa / ISMDO 98 has booked a sufficient number of rooms to accommodate
the expected number of participants for ISMDO 98. Accommodation has been
reserved both in hotels located within a 15 minute walk of the convention
centre or in suburbs directly linked to the city centre by buses. If some
delegates choose hotels located in the outer suburbs or on the seaside,
then they will have to arrange their own transportation, by car or by town
buses.
Hotel rates
Accommodation has been negotiated at a special symposium rate and only
rooms booked via your registration form will be available at these rates.
On the map, you can see where the hotels are located and in the following
page you can find descriptions and prices. The indicated rates (page 2
of the form) are per night including continental breakfast, hotel service
charges and government taxes.
How to make hotel reservations
Complete page 2 of your registration form and indicate three choices
of accommodation, by order of preference. The first choice will be allocated
on a first come, first served basis. You will receive all the information
regarding your accommodation at least two weeks before the meeting (hotel
location and vouchers). A deposit of one night is required for booking.
Please, include this amount in your registration fees. No reservation will
be made without deposit, and remember Montpellier is a touristic city and
the meeting takes place during the high season. Balance due may be paid
when receiving the invoice from Alpha Visa / ISMDO 98 before the meeting.
Deadline
We recommend you to secure your accommodation before May 15 1998. After
this date no guarantee can be provided and please first contact Alpha Visa
/ ISMDO 98.
Hotel Category
Hotels are selected as follows :
Hotels Category A : ****
Hotels Category B : ***
Residence Category B : ***
Hotels Category C : **
Students residence
Check In and Check Out
In most hotels, check in time is 14:00 and check out time is 11:00
Late arrivals
Please indicate if you will arrive at your hotel after 20:00
Change of booking
Any change of reservation before your arrival must be notified to ALPHA
VISA and not directly to the hotel. One modification of reservation is
allowed free of charge; further modification incurs an additional charge
of 60 FF per modification.
Cancellation
In case of cancellation :
before April 15: a cancellation fee of 50 FF will be charged
between April 15 and June 20: the equivalent of one night will be charged
after June 20: 50% of the total hotel reservation cost will be charged
(minimum one night)
HOTELS LIST - CHOICE OF ACCOMMODATION
The indicated prices are per room and per night and include continental
breakfast, hotel charges and government taxes.
HOTELS-Category A
CITY CENTRE
01 Hôtel Sofitel Antigone****
Recent building located in the town centre, 5 minute walk from the
Corum.
Air conditioning, soundproofed, telephone, TV (Canal+ & satellite),
mini-bar, room service. Swimming pool on the 8th stage.
Public car park : 70 FF/day
Single : 620 FF - Double : 620 FF
02 Holiday Inn Métropole****
Located in the town centre, 2 minute walk from the Place de la Comédie,
2 minute walk from the train station.
Air conditioning, telephone, TV (Canal+ & satellite), mini-bar,
mini-safe, room service. Restaurant. Car park : 40 FF / day
Single : 550 FF - Double : 600 FF
HOTELS-Category B
CITY CENTRE
03 Hôtel Astron***
Modern hotel located in the Antigone quarter, 5 minute drive from the
Corum or 15 walk.
Air conditioning, soundproofed, telephone, mini bar, room service
Swimming pool. Private car park
Single : 552 FF - Double : 623 FF
04 Hôtel Frantour Antigone***
In the heart of Montpellier, near the Polygone shopping centre, 5 minute
walk from the railway station and the Corum.
Soundproofed, telephone, TV (Canal+ & satellite), mini-bar. Restaurant.
Car park: 45 FF / day
Single : 476 FF - Double : 563 FF
05 Hôtel Mercure***
Recent building near the neo-classical quarter of Antigone, 10 minute
walk from the Corum, 15 minute walk from the railway station.
Air conditioning, telephone, TV. Restaurant.
Car park 45 FF / day
Single : 497 FF - Double : 593 FF
06 Hôtel Georges V***
Located at 800 m from the Corum
Air conditioning, soundproofed, telephone, TV. Restaurant.
Private car park : free
Single : 423 FF - Double : 508 FF
07 Royal Hôtel***
Located the Place de la Comédie right in the heart of Montpellier,
8 minute walk from the Corum.
Air conditioning, telephone TV (Canal +), mini bar, mini safe
Single : 357 FF - Double : 424 FF
08 New hôtel du Midi***
200 m from the railway station, 5 minute walk from the Corum, it is
located in the historic town centre on the Place de la Comédie.
Air conditioning, soundproofed, telephone, TV (Canal +), mini bar
Restaurant.. Public car park of la Comédie : 70 FF/per day
Single : 347 FF - Double : 424 FF
SUBURB
09 Golf-hôtel Fontcaude***
Located on a golf at 25 mn by car from the Corum.
Possibility to play golf.
Quiet, air conditioning, telephone, TV
Restaurant. Swimming pool.
Private car park : free
Single : 441 FF - Double : 575 FF
10 Novotel***
Modern hotel located at 15 mn by car from the Corum (regular town buses)
Air conditioning, telephone, TV, mini bar, room service
Restaurant - Swimming Pool - Private car park : free
Single : 517 FF - Double : 603 FF
RESIDENCES-Category B
11 Apparthôtel Citadines Antigone***
Hotel residence, 10 minute walk from the Corum, 15 minute walk from
the railway station. Studios for 1 or 2 people, 2 roomed flats for 2 or
3 people, kitchen facilities, air conditioning, telephone, TV (satellite).Ideal
for several people (e.g. family).
Car park : 35 FF / per day
Single studio : 333 FF
Double studio : 380 FF
Apartment double : 445 FF
Apartment triple : 540 FF
12 Apparthôtel Citadines Sainte Odile***
Hotel residence, 20 minutes by bus from the railway station and the
Corum. Studios for 1 or 2 people, 2 roomed flats for 2 or 3 people, kitchen
facilities, air conditioning, telephone, TV (satellite).Ideal for several
people (e.g. family).
Car park : 35 FF / per day
Single studio : 310 FF
Double studio : 348 FF
Apartment double : 391 FF
Apartment triple : 417 FF
HOTELS-Category C
CITY CENTRE
13 Hôtel Ibis Centre**
In the heart of Montpellier, near the Polygone shopping centre, 10
minute walk from the railway station and 6 minute walk from the Corum.
Air conditioning, TV, direct telephone, room service.
Restaurant. Car park : 45 FF / per day
Single : 346 FF - Double :406 FF
14 Hôtel Climat de France Antigone**
Near the centre of Antigone area of Montpellier, 10 minute walk from
the Corum.
Air conditioning, TV, telephone, room service.
Restaurant. Private car park : free
Single : 326 FF - Double : 366 FF
15 Hôtel Le Triangle**
Entirely renovated, this hotel is located next to the Polygone shopping
centre, 3 minutes walk from the Corum, 2 minute walk from the railway station.
Air conditioning, telephone, TV (Canal +)
Public car park : 80 FF/per day
Single : 400 FF - Double :451 FF
UNIVERSITY HALL OF RESIDENCE
16 Cité Universitaire de la Colombière
20 minutes by bus from the Corum and the railway station. Student room
with wash basin, WC and shower nearby. Sheets and blankets supplied but
not towels.
Single rooms only : 130 FF / per day
650 FF / per week
17 Cité Universitaire des Arceaux
20 minutes walking distance from the Corum. Student room with wash
basin, WC and shower nearby. Sheets and blankets supplied but not towels.
Single rooms only : 130 FF / per day
650 FF / per week
SOCIAL
PROGRAM FOR REGISTERED PARTICIPANTS
The cost of this program is included in the registration fees for
the participants and the accompanying guests.
Monday July 20
Opening reception
The opening reception will be held at Le Corum on Monday July 20 at
19:00. Beverages and a buffet will be served.
Tuesday July 21
Cocktail at Montpellier City Hall
Georges Frèche, the Mayor of Montpellier, will welcome participants
and accompanying guests at a cocktail which will be served at the City
Hall (at walking distance from Le Corum) on Tuesday July 21 between 19:00
and 21:00. This cocktail is offered by courtesy of Montpellier City Hall.
Wednesday 22 July
Wine and cheese party
A wine and cheese party will be organized at Le Corum on Wednesday
July 22 after the ceremony in honour of Professor Urs A Meyer. A collection
of local and other French wines will be served.
Thursday 23 July
Excursion and Banquet in Camargue
The banquet will be organized at a typical bull farm in La Camargue
(Le Mas de la Chassagne) on Thursday July 23. Buses will depart from Le
Corum at 17:00 and stop at Aigues-Mortes (a medieval walled city from where
King Saint Louis departed for crusades in 1192) or to the National Ornithological
Park of La Camargue (Saintes Maries de la Mer) before reaching the Mas
de la Chassagne.
La Grande Motte harbor
|
Cap d'Agde beach
|
OPTIONAL EXCURSIONS
For accompanying persons, one excursion (of their choice) is included in
the registration fees. The delegates and the accompanying persons may join
a walking guided tour of Montpellier historic center the day of their choice
(gratis). For additional optional excursions (see below), registration
should be made before the symposium to Alpha Visa / ISMDO 98 (see page
3 of the registration form)
Monday July 20
16:00 - 18:00 Walking guided tour of Montpellier historic centre.
Free for registered persons (registration before the symposium to Alpha
Visa / ISMDO 98).
Cost : 60 FF/person for non registered persons
Tuesday July 21
10:00 - 12:00 Walking guided tour of Montpellier historic centre.
Free for registered persons (registration before the symposium to Alpha
Visa / ISMDO 98).
Cost : 60 FF/person for non registered persons
14:00 - 18:00 Excursion to Saint Guilhem le Désert by coach
with a guide. Visit of St Guilhem, a romanesque village of the 11th
century with its typical architecture, known all over the world, founded
by Guilhem, a companion of Charlemagne. Followed by a visit to the glittering
underground word of the Grotte de Clamouse, an astonishing cave containing
exceptional stalactites and stalagmites.
Cost : 220 FF/person - Minimum of 30 participants
Wednesday July 22
8:00 - 19:00 Excursion to Carcassonne and Abbaye de Fontfroide.
Departure from Montpellier by coach with a guide (2 hour journey).Visit
of Carcassone. Because of its strategic position, the town was built as
a fortress in the middle ages. The town, which was restored in the 19th
century is considered as typical a medieval city. Lunch in Carcassonne.
In the afternoon, visit to another master piece from the middle ages, the
Abbaye de Fontfroide.
Cost : 440 FF /person for the day including meal - Minimum of 30 participants
Thursday July 23
10:00 - 12:00 Walking guided tour of Montpellier historic. Free
for registered persons (registration before the symposium to Alpha Visa
/ ISMDO 98.
Cost : 60 FF/person for non registered persons
14:00 -20:00 Excursion to the Camargue. Visit to the Listel
Cellars and tasting of the famous "Vin des sables". Aigues Mortes: this
13th century fortified city is an example of the military architecture
of the Middle ages. King St Louis choose the town, which was then a port,
for the departure of the last 2 crusades to Palestine.
In the Rhône delta, one enters the strange aquatic world of the
Camargue, inhabited by camargue horses and herds of black bulls reflected
in the sombre waters of the lakes, together with a typical flora and fauna
including fabulous pink flamingos. The village of Saintes Maries de la
Mer is a jewel of this region. At the end of the afternoon there is a visit
to a " manade" where one can watch games involving Camargue cows and drink
an aperitif together with a "brasoucade". Return to Montpellier at about
21:00 for those not staying to banquet.
Cost :200 FF /person (excursion only) - Minimum of 30 participants
17:00 - 24:00 Banquet in the Camargue. At the manade where the
aperitif is served, the participants and accompanying persons can have
dinner, a typical meal in a refitted former barn. Return by bus to Montpellier
between 23:00 and 2:00.
Cost :450 FF /person (banquet only, for non registered persons)
Cost : 500 FF /person for the excursion and the banquet (non registered
persons)
Friday July 24
8:00 - 18:00 Excursion to Nimes, Le Pont du Gard et Uzès.
Following the Roman track's, Nîmes with its remarkably well kept
monuments, the Arenas built in the first century B.C. and the "Maison Carrée",
a roman temple. The famous Pont du Gard, a roman aqueduct part of a 50
km long canalisation that used to bring drinking water to the inhabitants
of Nîmes form a spring located in Uzès. This impressive 50
m high aqueduct, with its three superimposed rows of arches, allows a wonderful
panoramic sight over the surrounding "Garrigue".
Cost : 440 FF /person for the day including meal - Minimum of 30 participants
10:00 - 12:00 Walking guided tour of Montpellier historic centre.
Free for registered persons (registration before the symposium to Alpha
Visa / ISMDO 98.
Cost : 60 FF/person for non registered persons
Saturday July 25
8:30 - 19:30 Excursion in Provence. One day trip to the land
of Vincent Van Gogh and Alphonse Daudet. Arles, les Baux de Provence, Moulin
de Daudet, Saint Rémy de Provence.
Cost :450 FF /person for the day including meal - Minimum of 30 participants
Maison Carrée (Nimes)
|
Pont du Gard
|
GENERAL INFORMATION
Symposium venue: Le Corum
The Symposium will be held in the Montpellier Convention Centre, Le
Corum, located within the historic centre of the city. Plenary lectures
will be presented in the Pasteur Auditorium (800 seats). Parallel session
lectures will be presented in the Pasteur and Einstein Auditoriums and
in the Salle Barthez. Oral communications will be presented in the Einstein
Auditorium. Posters displays, commercial exhibition, lunches and breaks
will be in Espace Joffre. Le Corum offers in addition, several facilities
including meeting rooms, restaurants and bars.
Le Corum: http://www.corum-montpellier.fr
(Tel: +33 4 67 61 67 61 - Fax: 33 4 67 61 67 69)
Montpellier
Montpellier and its suburbs
has about 350,000 inhabitants. It is the capital and largest city of the
Languedoc-Roussillon region. Montpellier was founded in 985 and since then
has continuously developed on a privileged site, facing to the south the
Mediterranean sea and backed to the north by the mountains of the Massif
Central (Les Cevènnes). Formed by its long history, Montpellier
offers two faces: the old town, small enough to walk around through the
narrow streets often lined with 18th century mansions and the
modern city, dynamic and developing as emphasised by the impressive building
complex of Antigone, created by the neo-classical architect Ricardo Boffil.
Montpellier is an important university town with 60,000 students spread
over 3 different universities covering 11 disciplines. Research plays a
major role (pharmacy, chemistry, computer sciences, electronics, agronomy,
biology, medicine, engineering, oceanography).
Departement of Hérault
The department of Hérault has 750,000 inhabitants and covering
6,200 km2. The main towns besides Montpellier are Béziers,
Sète, Agde, Lunel, Bédarieux, Pézenas, Lamalou les
Bains, each having its own charm. Two main rivers cross the department:
the Hérault river, from which the name of the department is derived
and the Orb river. You can appreciate natural landscapes such as the cirque
de Mourèze, the gorges d'Héric, the lac du Salagou, the lac
de La Salvetat, the étang de Thau, known for its oyster farm, Saint
Guilhem le Désert, and the nearby Pont du Diable. You can relax
on numerous sandy beaches (Valras, Cap d'Agde, Grau d'Agde, Sète,
Villeneuve les Maguelone, Palavas, Carnon, La Grande Motte, Grau du Roi,
Port Camargue). Most of the famous natural grottes are situated in the
department of Hérault (Les Demoiselles, Clamouse, La Devèze).
The department of Hérault is well known for its vineyards. Therefore,
take the time to taste some of our best vintages namely Minervois, Faugères,
Saint Chinian, Picpoul de Pinet, Listel, Cabrières, Saint Saturnin
and the famous Muscats matured in Frontignan, Mireval or Lunel.
Languedoc-Rousillon Region
The highly diverse region of Languedoc-Roussillon stretches from the
Southwest Pyrennees to the Northeast Cévennes mountains, and from
the Mediterranean coast in the south to the Massif Central in the north.
This region is composed of the following departments: Pyrennées
Orientales, Aude, Hérault, Gard and Lozère. This region is
quite unlike any other in France with, for instance, its own former language,
the "langue d'oc". It possesses very varied and spectacular landscapes:
the gorges du Tarn, the cirque de Navacelles, the Corniche des Cévennes,
the Causse Méjean, the Côte Vermeille, the Corbières
and the Petite Camargue. Most of the towns have preserved a rich heritage
of monuments dating from the Romans and even Greeks (Agde) to more recent
centuries: the Pont du Gard, the Arènes and the Maison Carrée
de Nimes (Roman), the Cités Médiévales of Aigues Mortes
and Carcassonne, the Château d'Uzès, the Cathedrals of Narbonne
and Béziers. The region is also famous of its astonishingly underground
natural caves (in addition to those already mentioned: Aven Armand, Trabuc,
Dargilan, Abîme de Bramabiau). Finally, you can relax on one of the
numerous sandy beaches: Banyuls, Collioure, Argeles, Canet, Port-Leucate,
Gruissan.
Weather and clothing
July in Montpellier is generally very sunny and hot (up to 35°C).
Do not forget your sun glasses and swimsuit. A light sweater or jacket
may be required if you wish to spend the evening on the sea front.
Letter of invitation
Upon request, the Organizing Committee will provide a letter of invitation
to those scientists who require such a letter solely in order to assist
them to obtain visa or travel funds from their home countries. On no account
will this letter dispense with the payment of the registration fees, travel
and housing. Please contact Alpha Visa / ISMDO 98 for further
information.
Insurance
French health care does not cover visitors to France. Please ensure
that you have suitable coverage from insurance policies from your home
country in the event of illness or accident while in France. For medical
cover, visitors from the European Union should bring the completed form
E111. Neither the Organizing Committee nor the International Advisory Committee
will accept liability for personal injuries sustained by or for loss or
damage to property belonging to Symposium participants either during or
as a result of the Symposium or during all tours.
Banking and credit cards
There are branches of the main French banks in Montpellier. Regular
banking hours are generally from 9:00 to 16:00 Monday to Friday. All branches
have automated teller machinesand are accessible on a 24 hours basis by
account holders. Most credit cards are accepted in France including Visa,
Mastercard, American Express and Diners card.
Sale tax
Refund of taxes on non-consumable items may be obtained for non - European
Union residents. Please make enquiries at Registration Desk during the
Symposium for more information.
Electrical current
The electrical current in France is 220 Volts 50 Hz ; 2 pin round plugs
Monetary exchange
The following guide gives exchange rates for the common currencies
of different countries in French Franc as of October 1997. These rates
are subject to change:
Austria: 0.504 Belgium: 0.173 Canada: 4.61
Denmark: 0.927 Germany: 3.53 Greece: 0.024
Ireland: 9.04 Italy: 0.004 Netherlands: 3.14
Norway : 0.882 Portugal: 0.036 Spain: 0.043
Sweden: 0.821 Switzerland: 4.23 United Kingdom: 10.0
USA: 6.28
Travel information
A valid passport or identity card is required for all visitors. No
visa is required for citizens from the European Union and from most other
European countries, North America, and Japan. For more information, please
contact your local French Embassy, Consulate or customs agent.
A public transportation system is operating in Montpellier city and
outlying areas (in particular to the beaches). Maps and further information
will be provided to the participants at the Symposium registration desk.
If you anticipate touring in the area, you should consider renting
a car from offices in Montpellier-Méditerrannée Airport or
in the city center. You are advised to reserve your car prior to your arrival
in Montpellier.
Festival of Radio-France and Montpellier
A Classical Music Festival is held every year during July-August in
Montpellier - Le Corum - Opera Berlioz. Further information about the program
and how to register can be accessed at the following sites:
Le Corum: http://www.corum-montpellier.fr
(Tel: +33 4 67 61 67 61 - Fax: 33 4 67 61 67 69)
Radio France: http://www.radio-france.fr
Fontfroide Abbaye Cloister
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Carcassonne city
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ACCESS TO MONTPELLIER
By car
The motorway network allows easy access from the main cities of Europe:
A9 form Spain, A8 from Italy, A7 from North Europe, A75 via the Massif
Central. Montpellier is located 465 miles from Paris by A7-A9. At Montpellier,
take the exit "Montpellier Est - Aéroport - Les Plages" and follow
the signs "Montpellier Centre" and "Le Corum" (near the historic centre).
An underground car park is located under the convention centre. You can
get weekly cards from the information desk in the convention centre, at
a special congress rate (30 FF / day).
By train
The high speed "TGV" train connects Paris to Montpellier in 4h30 minutes.
There are 8 TGVs daily to and from Paris - Gare de Lyon, and 2 TGVs to
and from the Paris - Charles de Gaulle airport. The later also serves Lille
with connection for London by Eurostar. There is an overnight train to
and from Paris with sleeping coaches. Other trains serve Brussels (TGV
via Lille), Amsterdam, Munich, Frankfurt, Geneva, Vienna, Barcelona and
Rome. A 20% discount within France is allowed if a special form is used
when booking with the SNCF (see page 4
of the registration form). Montpellier railway station is in the town centre
and the convention center and hotels can be reached by short walk or by
bus. The town buses have a stop in front of the station.
By air
Montpellier can be reached from all countries via Paris airports, Roissy
Charles de Gaulle and Orly. Flights to Montpellier leave either from Roissy
Charles de Gaulle terminal 2D (2 flights daily) or from Orly Ouest (10
flights daily).The flight takes about 1 hour and 15 minutes.
Roissy Charles de Gaulle terminal 2: Air France international flights
arrive at terminals 2A, 2C or 2D. Other airlines use Roissy Charles de
Gaulle terminal 1. To reach terminal 2D at Roissy, use the free shuttle
service. To transfer from Roissy to Orly, there is an Air France coach
leaving every 20 minutes (transfer time 50 minutes; 70 FF). If you arrive
on an Air France or Continental flight you can obtain a free coach ticket
at the Air France desk.
Transfer by taxi: 40 minutes; 300 FF for a maximum of 3 people in general.
Orly airport: International flights arrive at Orly Sud. For domestic
flights take the free shuttle to Orly Ouest.
Airports-Paris connections:
From Roissy Charles de Gaulle: either Air France coach every 12 minutes
(transfer time 15 minutes; 95 FF return); or Roissy-Rail every 15 minutes
(transfer time 27 minutes; 46 FF).
From Orly : either Air France coach every 12 minutes (transfer time
30 minutes; 65 FF return); or Orly-Val (automatic metro) every 7 minutes
(transfer time 30 minutes; 54 FF), or Orly-Rail every 15 minutes (transfer
time 35 minutes; 30 FF).
Montpellier Airport
Montpellier-Méditerranée airport is 8 km south of Montpellier.
There are direct flights from and to Florence, Geneva, London, Sonderborg,
Venice, Rome and several towns in France.
From Paris, there are 12 daily flights operated by Air France, AOM
and Air Liberté. A return ticket costs from 590 FF to 1080 FF. There
are reduced prices for couples, students and symposium participants. For
Air France Europe, you can ask ALPHA VISA / ISMDO 98 for a reduction certificate
which allows you a 35 % on the full fare. Reduced fares for international
flights if you spend the Saturday night in France.
Shuttle service Montpellier Airport - Le Corum
A special shuttle coach service "MDO98" will be arranged for Monday
July 20, 1998 between 14:00 and 22:00 and for Friday July 24, 1998 between
17:00 and 21:00. Times will be listed at the Airport information desk.
There is also a regular bus service to and from Montpellier city center
- railway station (transfer time 15 min, 25 FF). Transfer by taxi: 10 mn;
approx. 100 FF.
Car rental
Major car rental companies are represented in Montpellier airport,
railway station and city center. You can obtain special congress rates
(see page 4 of the registration form).
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Organising
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